Rat Narf ORF Clone(NM_001039207.2)

Name: Rat Narf ORF Clone(NM_001039207.2)
SKU: CDCR371732
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR371732

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Product Information

Gene Information

Cat. No.	CDCR371732
Product Type	ORF Clone
Gene Abbr	Narf
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1371 bp
Vector	pCMV6-Entry

Target Gene

NARF

Background

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]

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