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Rat Nagpa cDNA Clone(NM_001108265.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR007906

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Gene Information

Cat. No. CDFR007906
Description NativeORF clone of Rattus norvegicus N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (Nagpa) as transfection-ready DNA NM_001108265.1
Product Type cDAN Clone
Gene Abbr Nagpa
Species Rat
Vector pCMV6Entry
Target Gene NAGPA
Background Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015]
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