Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR007906
| Cat. No. | CDFR007906 |
| Description | NativeORF clone of Rattus norvegicus N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (Nagpa) as transfection-ready DNA NM_001108265.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Nagpa |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | NAGPA |
| Background | Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015] |
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