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Rat NFASC ORF clone(NM_001160314.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCH391737

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Product Information

Gene Information

Cat. No. CDCH391737
Product Type ORF clone
Gene Abbr NFASC
Species Rat
Host Cell Bacterial
Source Bacterial
ORF Size 9825bp
Size 1ug
Format Clear Liquid
Vector pORF
Buffer 10mM Tris-HCI, 1mM EDTA, pH8.0
Warning pORF-rNfasc ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage 1 year when stored at -20°C or lower in a non-frost free freezer.
Target Gene NFASC
Background This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
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