Rat Mus81 cDNA Clone(NM_001025645.1)

Name: Rat Mus81 cDNA Clone(NM_001025645.1)
SKU: CDFR004000
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR004000

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Product Information

Gene Information

Cat. No.	CDFR004000
Description	NativeORF clone of Rattus norvegicus MUS81 endonuclease homolog (S. cerevisiae) (Mus81) as transfection-ready DNA NM_001025645.1
Product Type	cDAN Clone
Gene Abbr	Mus81
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

MUS81

Background

This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]

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