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Rat Mthfd1 cDNA Clone(NM_022508.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011865

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Gene Information

Cat. No. CDFR011865
Description NativeORF clone of Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (Mthfd1) as transfection-ready DNA NM_022508.1
Product Type cDAN Clone
Gene Abbr Mthfd1
Species Rat
Vector pCMV6Entry
Target Gene MTHFD1
Background This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]
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