Rat Mllt11 cDNA Clone(NM_001013912.1)

Name: Rat Mllt11 cDNA Clone(NM_001013912.1)
SKU: CDFR002991
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002991

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Product Information

Gene Information

Cat. No.	CDFR002991
Description	NativeORF clone of Rattus norvegicus myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 (Mllt11) as transfection-ready DNA NM_001013912.1
Product Type	cDAN Clone
Gene Abbr	Mllt11
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

MLLT11

Background

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

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