Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR008183
| Cat. No. | CDFR008183 |
| Description | NativeORF clone of Rattus norvegicus mitogen activated protein kinase binding protein 1 (Mapkbp1) as transfection-ready DNA NM_001108589.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Mapkbp1 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | MAPKBP1 |
| Background | This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017] |
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