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Rat Mapkbp1 cDNA Clone(NM_001108589.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR008183

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Gene Information

Cat. No. CDFR008183
Description NativeORF clone of Rattus norvegicus mitogen activated protein kinase binding protein 1 (Mapkbp1) as transfection-ready DNA NM_001108589.1
Product Type cDAN Clone
Gene Abbr Mapkbp1
Species Rat
Vector pCMV6Entry
Target Gene MAPKBP1
Background This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]
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