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Rat Mapkapk5 cDNA Clone(NM_001025761.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR004104

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Gene Information

Cat. No. CDFR004104
Description NativeORF clone of Rattus norvegicus mitogen-activated protein kinase-activated protein kinase 5 (Mapkapk5) as transfection-ready DNA NM_001025761.2
Product Type cDAN Clone
Gene Abbr Mapkapk5
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene MAPKAPK5
Background The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
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