Rat Mapk8ip1 cDNA Clone(NM_053777.1)

Name: Rat Mapk8ip1 cDNA Clone(NM_053777.1)
SKU: CDFR013525
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013525

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Product Information

Gene Information

Cat. No.	CDFR013525
Description	NativeORF clone of Rattus norvegicus mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1) as transfection-ready DNA NM_053777.1
Product Type	cDAN Clone
Gene Abbr	Mapk8ip1
Species	Rat
Vector	pCMV6Entry

Target Gene

MAPK8IP1

Background

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

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