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Rat Lrrfip2 cDNA Clone(NM_001024761.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR003664

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Gene Information

Cat. No. CDFR003664
Description NativeORF clone of Rattus norvegicus leucine rich repeat (in FLII) interacting protein 2 (Lrrfip2) as transfection-ready DNA NM_001024761.1
Product Type cDAN Clone
Gene Abbr Lrrfip2
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene LRRFIP2
Background The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
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