Rat Loxl1 cDNA Clone(NM_001012125.1)

Name: Rat Loxl1 cDNA Clone(NM_001012125.1)
SKU: CDFR002552
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002552

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Product Information

Gene Information

Cat. No.	CDFR002552
Description	NativeORF clone of Rattus norvegicus lysyl oxidase-like 1 (Loxl1) as transfection-ready DNA NM_001012125.1
Product Type	cDAN Clone
Gene Abbr	Loxl1
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

LOXL1

Background

This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]

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