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Rat Lin28a cDNA Clone(NM_001109269.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR008856

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Gene Information

Cat. No. CDFR008856
Description NativeORF clone of Rattus norvegicus lin-28 homolog (C. elegans) (Lin28) as transfection-ready DNA NM_001109269.1
Product Type cDAN Clone
Gene Abbr Lin28a
Species Rat
Vector pCMV6Entry
Target Gene LIN28A
Background This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]
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