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Rat Lats2 cDNA Clone(NM_001107267.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006988

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Gene Information

Cat. No. CDFR006988
Description NativeORF clone of Rattus norvegicus large tumor suppressor 2 (Lats2) as transfection-ready DNA NM_001107267.1
Product Type cDAN Clone
Gene Abbr Lats2
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene LATS2
Background This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
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