Rat Kidins220 cDNA Clone(NM_053795.1)

Name: Rat Kidins220 cDNA Clone(NM_053795.1)
SKU: CDFR013537
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013537

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Product Information

Gene Information

Cat. No.	CDFR013537
Description	NativeORF clone of Rattus norvegicus kinase D-interacting substrate 220 (Kidins220) as transfection-ready DNA NM_053795.1
Product Type	cDAN Clone
Gene Abbr	Kidins220
Species	Rat
Vector	pCMV6Entry

Target Gene

KIDINS220

Background

This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

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