Rat Kdm2a cDNA Clone(NM_001108515.1)

Name: Rat Kdm2a cDNA Clone(NM_001108515.1)
SKU: CDFR008127
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008127

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Product Information

Gene Information

Cat. No.	CDFR008127
Description	NativeORF clone of Rattus norvegicus F-box and leucine-rich repeat protein 11 (Fbxl11) as transfection-ready DNA NM_001108515.1
Product Type	cDAN Clone
Gene Abbr	Kdm2a
Species	Rat
Vector	pCMV6Entry

Target Gene

KDM2A

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

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