Rat Kdelr2 cDNA Clone(NM_001013122.1)

Name: Rat Kdelr2 cDNA Clone(NM_001013122.1)
SKU: CDFR002848
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002848

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Product Information

Gene Information

Cat. No.	CDFR002848
Description	NativeORF clone of Rattus norvegicus KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 (Kdelr2) as transfection-ready DNA NM_001013122.1
Product Type	cDAN Clone
Gene Abbr	Kdelr2
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

KDELR2

Background

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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