Rat Kcnq1 ORF Clone(NM_032073.1)

Name: Rat Kcnq1 ORF Clone(NM_032073.1)
SKU: CDCR380023
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR380023

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Product Information

Gene Information

Cat. No.	CDCR380023
Product Type	ORF Clone
Gene Abbr	Kcnq1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2010 bp
Vector	pCMV6-Entry

Target Gene

KCNQ1

Background

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

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