Rat Kcnj11 ORF Clone(NM_031358.3)

Name: Rat Kcnj11 ORF Clone(NM_031358.3)
SKU: CDCR379696
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR379696

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Product Information

Gene Information

Cat. No.	CDCR379696
Product Type	ORF Clone
Gene Abbr	Kcnj11
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1173 bp
Vector	pCMV6-Entry

Target Gene

KCNJ11

Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

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