Rat Itpr2 cDNA Clone(NM_031046.3)

Name: Rat Itpr2 cDNA Clone(NM_031046.3)
SKU: CDFR012522
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012522

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Product Information

Gene Information

Cat. No.	CDFR012522
Description	NativeORF clone of Rattus norvegicus inositol 1,4,5-triphosphate receptor, type 2 (Itpr2) as transfection-ready DNA NM_031046.3
Product Type	cDAN Clone
Gene Abbr	Itpr2
Species	Rat
Vector	pCMV6Entry

Target Gene

ITPR2

Background

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]

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