Rat Incenp cDNA Clone(NM_001106335.1)

Name: Rat Incenp cDNA Clone(NM_001106335.1)
SKU: CDFR006078
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006078

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Product Information

Gene Information

Cat. No.	CDFR006078
Description	NativeORF clone of Rattus norvegicus inner centromere protein (Incenp) as transfection-ready DNA NM_001106335.1
Product Type	cDAN Clone
Gene Abbr	Incenp
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

INCENP

Background

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]

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