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Rat Impa1 cDNA Clone(NM_032057.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR012995

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Gene Information

Cat. No. CDFR012995
Description NativeORF clone of Rattus norvegicus Inositol (myo)-1(or 4)-monophosphatase 1 (Impa1) as transfection-ready DNA NM_032057.1
Product Type cDAN Clone
Gene Abbr Impa1
Species Rat
Vector pCMV6Entry
Target Gene IMPA1
Background This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
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