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Rat Il13 ORF Clone(NM_053828.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR380597

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Gene Information

Cat. No. CDCR380597
Product Type ORF Clone
Gene Abbr Il13
Species Rat
Tag C-terminal Myc-DDK
ORF Size 396 bp
Vector pCMV6-Entry
Target Gene IL13
Background This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
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