Rat Ifih1 cDNA Clone(NM_001109199.1)

Name: Rat Ifih1 cDNA Clone(NM_001109199.1)
SKU: CDFR008739
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008739

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Product Information

Gene Information

Cat. No.	CDFR008739
Description	NativeORF clone of Rattus norvegicus interferon induced with helicase C domain 1 (Ifih1) as transfection-ready DNA NM_001109199.1
Product Type	cDAN Clone
Gene Abbr	Ifih1
Species	Rat
Vector	pCMV6Entry

Target Gene

IFIH1

Background

IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]

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