Rat Idh3B cDNA Clone(NM_053581.1)

Name: Rat Idh3B cDNA Clone(NM_053581.1)
SKU: CDFR013303
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013303

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Product Information

Gene Information

Cat. No.	CDFR013303
Description	NativeORF clone of Rattus norvegicus isocitrate dehydrogenase 3 (NAD+) beta (Idh3B), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_053581.1
Product Type	cDAN Clone
Gene Abbr	Idh3B
Species	Rat
Vector	pCMV6Entry

Target Gene

IDH3B

Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2016]

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