Rat Idh2 cDNA Clone(NM_001014161.1)

Name: Rat Idh2 cDNA Clone(NM_001014161.1)
SKU: CDFR003287
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR003287

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Product Information

Gene Information

Cat. No.	CDFR003287
Description	NativeORF clone of Rattus norvegicus isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001014161.1
Product Type	cDAN Clone
Gene Abbr	Idh2
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

IDH2

Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

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