Rat Ide ORF Clone(NM_013159.1)

Name: Rat Ide ORF Clone(NM_013159.1)
SKU: CDCR377993
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377993

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Product Information

Gene Information

Cat. No.	CDCR377993
Product Type	ORF Clone
Gene Abbr	Ide
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	3060 bp
Vector	pCMV6-Entry

Target Gene

IDE

Background

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

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