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Rat IL17RC ORF clone(NM_001170565.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCH386941

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Product Information

Gene Information

Cat. No. CDCH386941
Product Type ORF clone
Gene Abbr IL17RC
Species Rat
Host Cell Bacterial
Source Bacterial
ORF Size 2322bp
Size 1ug
Format Clear Liquid
Vector pORF
Buffer 10mM Tris-HCI, 1mM EDTA, pH8.0
Warning pORF-rIl17rc ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage 1 year when stored at -20°C or lower in a non-frost free freezer.
Target Gene IL17RC
Background This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
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