Rat IL12RB2 ORF clone(NM_001191750.1)

Name: Rat IL12RB2 ORF clone(NM_001191750.1)
SKU: CDCL184755
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL184755

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Product Information

Gene Information

Cat. No.	CDCL184755
Description	ORF Clone of Rattus norvegicus interleukin 12 receptor, beta 2 DNA.
Product Type	ORF clone
Gene Abbr	IL12RB2
Species	Rat
ORF Size	2610bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

IL12RB2

Background

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

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