Rat Hras cDNA Clone(NM_001098241.1)

Name: Rat Hras cDNA Clone(NM_001098241.1)
SKU: CDFR005156
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR005156

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Product Information

Gene Information

Cat. No.	CDFR005156
Description	NativeORF clone of Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant 2 as transfection-ready DNA NM_001098241.1
Product Type	cDAN Clone
Gene Abbr	Hras
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

HRAS

Background

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

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