Rat Hoga1 cDNA Clone(NM_001106355.1)

Name: Rat Hoga1 cDNA Clone(NM_001106355.1)
SKU: CDFR006094
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006094

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Product Information

Gene Information

Cat. No.	CDFR006094
Description	NativeORF clone of Rattus norvegicus similar to RIKEN cDNA 0610010D20 (RGD1310475) as transfection-ready DNA NM_001106355.1
Product Type	cDAN Clone
Gene Abbr	Hoga1
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

HOGA1

Background

The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]

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