Rat Gtf2h2 cDNA Clone(NM_001077428.1)

Name: Rat Gtf2h2 cDNA Clone(NM_001077428.1)
SKU: CDFR004975
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR004975

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Product Information

Gene Information

Cat. No.	CDFR004975
Description	NativeORF clone of Rattus norvegicus general transcription factor IIH, polypeptide 2 (Gtf2h2) as transfection-ready DNA NM_001077428.1
Product Type	cDAN Clone
Gene Abbr	Gtf2h2
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

GTF2H2

Background

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008]

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