Rat Gstm3 cDNA Clone(NM_020540.1)

Name: Rat Gstm3 cDNA Clone(NM_020540.1)
SKU: CDFR011675
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011675

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Product Information

Gene Information

Cat. No.	CDFR011675
Description	NativeORF clone of Rattus norvegicus glutathione S-transferase mu 3 (Gstm3) as transfection-ready DNA NM_020540.1
Product Type	cDAN Clone
Gene Abbr	Gstm3
Species	Rat
Vector	pCMV6Entry

Target Gene

GSTM3

Background

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

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