Rat Gstm1 cDNA Clone(NM_017014.1)

Name: Rat Gstm1 cDNA Clone(NM_017014.1)
SKU: CDFR011084
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011084

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Product Information

Gene Information

Cat. No.	CDFR011084
Description	NativeORF clone of Rattus norvegicus glutathione S-transferase mu 1 (Gstm1) as transfection-ready DNA NM_017014.1
Product Type	cDAN Clone
Gene Abbr	Gstm1
Species	Rat
Vector	pCMV6Entry

Target Gene

GSTM1

Background

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

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