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Rat Gria4 ORF Clone(NM_001113185.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR376343

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Product Information

Gene Information

Cat. No. CDCR376343
Product Type ORF Clone
Gene Abbr Gria4
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1302 bp
Vector pCMV6-Entry
Target Gene GRIA4
Background Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
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