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Rat Grb10 cDNA Clone(NM_001109093.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR008640

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Gene Information

Cat. No. CDFR008640
Description NativeORF clone of Rattus norvegicus growth factor receptor bound protein 10 (Grb10) as transfection-ready DNA NM_001109093.1
Product Type cDAN Clone
Gene Abbr Grb10
Species Rat
Vector pCMV6Entry
Target Gene GRB10
Background The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
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