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Rat Gps2 ORF Clone(NM_001017477.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR370519

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Gene Information

Cat. No. CDCR370519
Product Type ORF Clone
Gene Abbr Gps2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 984 bp
Vector pCMV6-Entry
Target Gene GPS2
Background This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
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