Rat Gpi cDNA Clone(NM_207592.1)

Name: Rat Gpi cDNA Clone(NM_207592.1)
SKU: CDFR015341
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR015341

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Product Information

Gene Information

Cat. No.	CDFR015341
Description	NativeORF clone of Rattus norvegicus glucose phosphate isomerase (Gpi) as transfection-ready DNA NM_207592.1
Product Type	cDAN Clone
Gene Abbr	Gpi
Species	Rat
Vector	pCMV6Entry

Target Gene

GPI

Background

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

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