Rat Gne cDNA Clone(NM_053765.2)

Name: Rat Gne cDNA Clone(NM_053765.2)
SKU: CDFR013513
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013513

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Product Information

Gene Information

Cat. No.	CDFR013513
Description	NativeORF clone of Rattus norvegicus glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Gne) as transfection-ready DNA NM_053765.2
Product Type	cDAN Clone
Gene Abbr	Gne
Species	Rat
Vector	pCMV6Entry

Target Gene

GNE

Background

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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