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Rat Gle1 cDNA Clone(NM_001025731.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR004085

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Gene Information

Cat. No. CDFR004085
Description NativeORF clone of Rattus norvegicus GLE1 RNA export mediator homolog (yeast) (Gle1) as transfection-ready DNA NM_001025731.1
Product Type cDAN Clone
Gene Abbr Gle1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene GLE1
Background This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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