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Rat Gfi1 ORF Clone(NM_012566.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377302

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Gene Information

Cat. No. CDCR377302
Product Type ORF Clone
Gene Abbr Gfi1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1272 bp
Vector pCMV6-Entry
Target Gene GFI1
Background This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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