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Rat Fyco1 ORF Clone(NM_001106870.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR373648

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Gene Information

Cat. No. CDCR373648
Product Type ORF Clone
Gene Abbr Fyco1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 4356 bp
Vector pCMV6-Entry
Target Gene FYCO1
Background The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]
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