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Rat Fcgr3a cDNA Clone(NM_207603.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR015352

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Gene Information

Cat. No. CDFR015352
Description NativeORF clone of Rattus norvegicus Fc fragment of IgG, low affinity IIIa, receptor (Fcgr3a) as transfection-ready DNA NM_207603.1
Product Type cDAN Clone
Gene Abbr Fcgr3a
Species Rat
Vector pCMV6Entry
Target Gene CD16A
Background This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
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