Rat Fbxo32 cDNA Clone(NM_133521.1)

Name: Rat Fbxo32 cDNA Clone(NM_133521.1)
SKU: CDFR014040
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014040

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Product Information

Gene Information

Cat. No.	CDFR014040
Description	NativeORF clone of Rattus norvegicus F-box protein 32 (Fbxo32) as transfection-ready DNA NM_133521.1
Product Type	cDAN Clone
Gene Abbr	Fbxo32
Species	Rat
Vector	pCMV6Entry

Target Gene

FBXO32

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

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