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Rat Fbn1 ORF Clone(NM_031825.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379969

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Product Information

Gene Information

Cat. No. CDCR379969
Product Type ORF Clone
Gene Abbr Fbn1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 8619 bp
Vector pCMV6-Entry
Target Gene FBN1
Background This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016]
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