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Rat Fbln5 cDNA Clone(NM_019153.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011451

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Gene Information

Cat. No. CDFR011451
Description NativeORF clone of Rattus norvegicus fibulin 5 (Fbln5) as transfection-ready DNA NM_019153.3
Product Type cDAN Clone
Gene Abbr Fbln5
Species Rat
Vector pCMV6Entry
Target Gene FBLN5
Background The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
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