Rat Far1 cDNA Clone(NM_001011933.1)

Name: Rat Far1 cDNA Clone(NM_001011933.1)
SKU: CDFR002364
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002364

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Product Information

Gene Information

Cat. No.	CDFR002364
Description	NativeORF clone of Rattus norvegicus fatty acyl CoA reductase 1 (Far1) as transfection-ready DNA NM_001011933.1
Product Type	cDAN Clone
Gene Abbr	Far1
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

FAR1

Background

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]

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