Rat Fam111a cDNA Clone(NM_001109163.1)

Name: Rat Fam111a cDNA Clone(NM_001109163.1)
SKU: CDFR008708
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008708

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Product Information

Gene Information

Cat. No.	CDFR008708
Description	NativeORF clone of Rattus norvegicus family with sequence similarity 111, member A (Fam111a) as transfection-ready DNA NM_001109163.1
Product Type	cDAN Clone
Gene Abbr	Fam111a
Species	Rat
Vector	pCMV6Entry

Target Gene

FAM111A

Background

The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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