Rat Epb49 cDNA Clone(NM_001108385.1)

Name: Rat Epb49 cDNA Clone(NM_001108385.1)
SKU: CDFR008006
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008006

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Product Information

Gene Information

Cat. No.	CDFR008006
Description	NativeORF clone of Rattus norvegicus erythrocyte protein band 4.9 (Epb4.9) as transfection-ready DNA NM_001108385.1
Product Type	cDAN Clone
Gene Abbr	Epb49
Species	Rat
Vector	pCMV6Entry

Target Gene

EPB49

Background

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

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