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Rat Edn3 ORF Clone(NM_001077650.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR372070

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Product Information

Gene Information

Cat. No. CDCR372070
Product Type ORF Clone
Gene Abbr Edn3
Species Rat
Tag C-terminal Myc-DDK
ORF Size 504 bp
Vector pCMV6-Entry
Target Gene EDN3
Background The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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