Rat ESPL1 ORF clone(NM_001170602.1)

Name: Rat ESPL1 ORF clone(NM_001170602.1)
SKU: CDCG000437
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCG000437

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Product Information

Gene Information

Cat. No.	CDCG000437
Product Type	ORF clone
Gene Abbr	ESPL1
Species	Rat
Host Cell	Bacterial
Source	Bacteria
ORF Size	6835bp
Size	1ug
Format	Clear Liquid
Vector	pORF
Buffer	10mM Tris-HCI, 1mM EDTA, pH8.0
Warning	pORF-rEspl1 ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage	1 year when stored at -20°C or lower in a non-frost free freezer.

Target Gene

ESPL1

Background

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

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